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Comparison of Pulpal Inflammation and levels of biomarkers(MMP-9 and Presepsin) in tooth blood samples in two different conditions

Comparative assessment of degree of pulpal inflammation and the levels of MMP-9 and Presepsin biomarkers in moderate and severe pulpitis: A Randomized controlled study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/07/113290
Enrollment
44
Registered
2026-07-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: NIL: NIL Intervention4: Nil: Nil Control Intervention1: NIL: NIL

Sponsors

Vinayaka Missions Sankarachariyar Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Maxillary and mandibular 1st and 2nd molars with Class I dental caries. Positive cold test response. Diagnosis based on Wolters classification as moderate and completely irreversible pulpitis. Vital pulp confirmed after access opening from all the orifices.

Exclusion criteria

Exclusion criteria: Teeth with previous endodontic therapy, crwons, or extensive restorations. Patients with systemic illness or conditions that impair healing, such as immunocompromised individuals. Teeth with periodontal pockets more than 3mm or advanced periodontal disease. Acute periapical abscess or cellulitis.

Design outcomes

Primary

MeasureTime frame
To measure the levels of respective biomarkers in moderate and severe pulpitisTimepoint: Baseline—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr DIVYAMEENA B

VINAYAKA MISSIONS SANKARACHARIYAR DENTAL COLLEGE

drdivyameenab@vmsdc.edu.in9952463468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026