Comparison of Three Treatment Methods for Reducing Dark Gum Pigmentation: Vitamin C, Diode Laser, and Surgery

Comparative evaluation of Vitamin C Mesotherapy, Diode Laser (980nm) and Conventional surgery in the treatment of Physiologic Gingival Hyperpigmentation- Clinical and Histological study- A Double-blind Non-Randomized Controlled trial. - DEPIG-3 Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/07/113262

Enrollment

Registered

2026-07-02

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: vitamin c laser scalpel: Vit C is used for gingival hyperpigmentation by mesotherapy, laser is used for gingival hyperpigmentation by absorption of wavelength by melanin, scalpel scrape

Eligibility

Inclusion criteria

Inclusion criteria: Diffuse continuous physiological pigmentation of the gingiva involving the facial aspect of teeth classified under Dummet Oral Pigmentation Index minimum score 2. Systemically and periodontally healthy male and female with an age range of 18-40 years. Patient with esthetic concern due to gingival hyperpigmentation. Patients with good oral hygiene.

Exclusion criteria

Exclusion criteria: Patients suffering from any known systemic diseases. Individuals with a habit of smoking tobacco chewing. Patients with drugs intake such as antimalarial drugs phenothiazine oral contraceptives. Pregnant and lactating mothers. Patients with periodontal disease. Patients with known hypersentivity to ascorbic acid. Patient undergone gingival depigmentation within last 1 year.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare efficacy of vitamin c mesotherapy and diode laser and conventional surgical technique in the treatment of gingival hyperpigmentation by change in clinical and histological parametersTimepoint: At baseline,1 week,4 weeks	—

Secondary

Measure	Time frame
compare the efficacy between three different techniquesTimepoint: 3 months	—

Countries

India

Contacts

Public ContactDr Prarthana Mantri

DR HSRSM DENTAL COLLEGE, HINGOLI-431513

mantriprarthana@gmail.com8605545928

Outcome results