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A study comparing two breathing methods during abdominal surgery to see their effect on lung function

Driving pressures with versus without recruitment manoeuvre and PEEP Titration in patients undergoing upper abdominal laparotomy under general anaesthesia and thoracic epidural anaesthesia: A Randomised non inferiority trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/07/113249
Enrollment
120
Registered
2026-07-02
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere

Interventions

Intervention1: Lung protective ventilation strategies: withdrawal of Recruitment manoeuvres and PEEP Titration in upper abdominal laparotomy under general anaesthesia and thoracic epidural anaesthesia

Sponsors

AIIMS, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-65 2. ASA I-II 3. Elective open laparotomy cases requiring subcostal incisions under general anaesthesia + TEA with duration greater than 2 hours

Exclusion criteria

Exclusion criteria: 1. Non-consenting patients 2. Pre-existing significant lung disease in last 4 weeks 3. COPD, Bronchial asthma, ILD 4. BMI more than 35kg/m2 5. Hemodynamic instability 6. Contraindications to epidural anaesthesia 7. Failed Thoracic epidural anaesthesia

Design outcomes

Primary

MeasureTime frame
Difference in the Driving pressures in the two groupsTimepoint: At Baseline, every 30 minutes, End of surgery—

Secondary

MeasureTime frame
Incidence of post operative pulmonary complications within 7 days such as post operative atelectasis, respiratory infections, aspiration pneumonia, pneumothorax, bronchospasm, pleural effusionTimepoint: At 1 week from surgery;Intraoperative hemodynamic parametersTimepoint: At baseline, every 5 minutes, end of surgery;Dynamic & Static lung complianceTimepoint: At baseline, every 30 minutes, end of surgery;Intraoperative oxygenation (Pao2/FiO2)Timepoint: At baseline, end of surgery—

Countries

India

Contacts

Public ContactDr Dominic Vipin

All India Institute of Medical Science, New Delhi

rashmiramachandran1@gmail.com8197021123

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026