Effect of high protein nutrition and growth hormone on recovery in critically ill children

Augmented protein enteral nutrition combined with Recombinant human growth hormone (rh GH) in reduces the duration of hospital stay in critically ill, mechanically ventilated children compared to standard enteral nutrition: A Randomized Controlled Trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/113187

Enrollment

100

Registered

2026-06-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I999- Unspecified disorder of circulatory system

Interventions

Intervention1: Arm 2: Standard protein enteral nutrition plus rhGH Intervention2: Arm 3: Augmented protein enteral nutrition Intervention3: Augmented protein enteral nutrition and recombinant growth h

Eligibility

Inclusion criteria

Inclusion criteria: children admitted to PICU aged between 1 month and 15 years on mechanical ventilation for 72 hours with stable or improving organ score and on enteral nutrition

Exclusion criteria

Exclusion criteria: Children with an acute kidney injury score of 3, fluid overload of more than 10 per cent, suspected or known inborn error of metabolism or with acute liver failure

Design outcomes

Primary

Measure	Time frame
To compare hospital free days at day 90 between the control group and the intervention groupTimepoint: At day 90 after enrollment	—

Secondary

Measure	Time frame
Duration of Mechanical Ventilation PICU Mortality PICU Length of Stay (LOS) Change in Anthropometry Change in Lean Body Mass (via BIA) Adverse Events Timepoint: during PICU stay	—

Countries

India

Contacts

Public ContactSANTOSH NAVI

AIIMS RAIPUR

drmrsahoo@gmail.com7893230151

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026