Health Condition 1: I693- Sequelae of cerebral infarction
Conditions
Interventions
Intervention1: Active tDCS: Active tDCS (20 minutes) combined with motor training and standard care for 4 weeks, with a total session duration of 1 hour.
Control Intervention1: Sham tDCS: Sham tDCS (2
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged more than 18 years to 70 years Diagnosed anterior circulation ischemic stroke in the past 3 to 6 months Persistent upper-limb motor impairment (e.g., FMA-UE less than 48) Ability to sit upright and engage in motor tasks Capable of understanding instructions (English/Hindi) Residing at home with a caregiver available for assistance (if needed) fMRI/EEG compatible and able to undergo pre/post scans Willing to provide written informed consent
Exclusion criteria
Exclusion criteria: History of seizures or epilepsy, or current anti-epileptic medication usage Presence of major neurological/psychiatric conditions other than stroke Metallic implants in the head (excluding dental fillings) Presence of pacemaker/other implanted neurostimulators Severe cognitive impairment affecting consent or task participation Pregnant or lactating women Uncontrolled hypertension or cardiac instability Skin lesions or dermatological conditions at electrode sites Contraindications to MRI (claustrophobia, implants, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl Meyer Assessment- Upper Limb at baseline and week 5Timepoint: At baseline and week 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl Meyer Assessment- Upper Limb at week 17Timepoint: At week 17;Modified Barthel Index at baseline , week 5 & week 17Timepoint: at baseline , week 5 & week 17;fMRI at baseline , week 5 & week 17Timepoint: at baseline , week 5 & week 17;Feasibility Adherence rate: Proportion of participants completing more than equal to 80% of prescribed home-based tDCS sessionsTimepoint: ;Safety Outcome: Adverse event monitoring: Incidence and severity of stimulation- related eventsTimepoint: | — |
Countries
India
Contacts
Public ContactDr Ayush Agarwal
All India Institute of Medical Sciences
Outcome results
None listed