Reducing Pain and Anxiety During Dental Injections in Children: A Comparison of Cooling Spray and Numbing Spray

Comparative Evaluation of Cryotherapy and Topical Anesthesia on Pain Perception and Anxiety in Children: A Split-Mouth Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/113157

Enrollment

Registered

2026-06-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Group 1: Cryotherapy (Pre-cooling): Endo-Frost spray will be applied to a cotton swab. Before intraoral application, the temperature of the cotton swab will be measured using a digital

Eligibility

Inclusion criteria

Inclusion criteria: 1. Children age group of 5-10 years. 2. Healthy children attending the dental hospital. 3. Children who are willing to participate in the study. 4. Children who require local infiltration for dental procedures.

Exclusion criteria

Exclusion criteria: 1. Children with special health care needs. 2. Children with systemic disorders. 3. Children with dental emergencies like trauma.

Design outcomes

Primary

Measure	Time frame
Reduction in the anxiety and pain perception during administration of local infiltration following pre-cooling in children.Timepoint: 2 months	—

Secondary

Measure	Time frame
Reduction in the pain perception during administration of local infiltration following pre treatment using Cryotherapy & Topical Anaesthetic sprayTimepoint: During & after local anesthetic administration	—

Countries

India

Contacts

Public ContactDr Nandini Prasad

Narayana Dental College and Hospital, Chinthareddypalem, Nellore

nimskrishna2007@gmail.com9440206976

Outcome results