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A crossover randomized controlled trial comparing the effectiveness of two anesthetic solutions, 4 percent articaine and 2 percent lidocaine, with and without intrapulpal anesthesia in inferior alveolar nerve block during root canal treatment.

Efficacy of two anesthetic solutions 4 percent articaine and 2 percent lidocaine with and without intrapulpal anesthesia in inferior alveolar nerve block- a crossover randomized controlled trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/113110
Enrollment
15
Registered
2026-06-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 4 percent Articaine: Articaine hydrochloride 4 percent is an amide type local anesthetic with superior tissue penetration and rapid onset of action. Owing to its unique thiophene ring a

Sponsors

Maithilee Sapkal
Lead Sponsor
Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital Nagpur
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients with irreversible pulpitis without any periapical change. Patients with bilateral molar RCTs. Patients requiring inferior alveolar nerve block. Healthy patients Patient who have not taken any antibiotic and analgesic before treatment. Patients willing to provide informed consent. Patients without systemic diseases.

Exclusion criteria

Exclusion criteria: 1. Patients with known allergy to Amide LA. 2. Patients with Systemic diseases. 3. Patients in which LA is contraindicated 4. Pregnant & lactating women. 5. Necrotic pulp. 6. Teeth in which endodontic treatment is previously initiated.

Design outcomes

Primary

MeasureTime frame
Pain during access cavity preparation.Timepoint: BEFORE ADMINISTRATION OF LA,AFTER ADMINISTRATION OF LA,DURING ACCESS OPENING.—

Secondary

MeasureTime frame
Onset time of anesthesia, need for intrapulpal anesthesia, anesthetic success rateTimepoint: baseline—

Countries

India

Contacts

Public ContactMaithilee Sapkal

Swargiya dadasaheb smruti dental college and hospital , nagpur

aartilamb1995@gmail.com8237409903

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026