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Exploring the Relationship Between Fatty Liver Disease, Depression, and Systemic Inflammatory Markers

A Prospective Cross Sectional Clinical Observational Study to Explore Depressive Symptoms and Systemic Inflammatory Markers in Patients with Non Alcoholic Fatty Liver Disease NAFLD and Individuals without NAFLD - MIND-NAFLD

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/113109
Enrollment
180
Registered
2026-06-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E349- Endocrine disorder, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil Intervention5: Nil: Nil Intervention6: Nil: Nil

Sponsors

SUHANI SHARMA
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All eligible patients diagnosed with NAFLD and individuals without NAFLD were recruited consecutively and included in the study after obtaining informed consent.

Exclusion criteria

Exclusion criteria: Participants with significant alcohol intake, viral hepatitis or other chronic liver diseases, pregnancy or lactation, severe psychiatric disorders precluding questionnaire completion, inability or unwillingness to provide informed consent, and those with incomplete clinical, laboratory, or questionnaire data were excluded from the study.

Design outcomes

Primary

MeasureTime frame
1 Prevalence and severity of depressive symptoms in patients with NAFLD assessed using the Patient Health Questionnaire 9 score at baseline. 2 Association between hepatic steatosis and liver fibrosis severity assessed by FibroScan and systemic inflammatory indices including Neutrophil Lymphocyte Ratio. Platelet Lymphocyte Ratio, and Systemic Immune Inflammation Index, along with depression scores PHQ 9 among NAFLD patients and individuals without NAFLD at baseline. Timepoint: SINGLE TIME POINT

Secondary

MeasureTime frame
3. Quality of life assessment in patients with NAFLD using the WHO Quality of Life BREF questionnaire at baseline. 4. Severity grading of hepatic steatosis & liver fibrosis using FibroScan & evaluation of its association with the following demographic & clinical variables at baseline 1. Age 2. Gender 3. Dietary pattern 4. Socioeconomic status, assessed using the Modified Kuppuswamy Socioeconomic Status Scale. Timepoint: SINGLE TIME POINT

Countries

India

Contacts

Public ContactDr Mohd Ashif Khan

Fortis Escorts Heart Institute and Research Centre

drsurakshithtk@gmail.com9560083977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026