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Effectiveness of Adding Magnesium Sulphate to Articaine During Mandibular Third Molar Surgery

The Synergistic Effect of Adding Magnesium Sulphate to 4% Articaine With 1:100000 Adrenaline in Mandibular Third Molar Surgery:A Randomised Controlled Study - NIL

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/113105
Enrollment
60
Registered
2026-06-29
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: 4% Articaine with 1:100000 Adrenaline + Magnesium Sulphate: Experimental group: Inferior Alveolar nerve block administered using 4% Articaine with 1:100000 Adrenaline supplemented with

Sponsors

ICARE INSTITUTE OF MEDICAL SCIENCES AND RESEARCH AND DR B C ROY HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients requiring surgical extraction of impacted mandibular third molars. 1. ASA Grade I or II patients. 2. Patients willing to participate and provide written informed consent. 3. Patients able to comply with study protocol and follow-up visits.

Exclusion criteria

Exclusion criteria: Allergy or hypersensitivity to Articaine, Magnesium Sulphate, or study medications. 1. Pregnancy or lactation. 2. Systemic diseases contraindicating oral surgery. 3. Acute infection at injection or surgical site. 4. History of neurological disorders affecting pain perception. 5. Patients taking analgesics, sedatives, or anti-inflammatory drugs within 24 hours before surgery. 6. Uncooperative patients or those unwilling to provide consent.

Design outcomes

Primary

MeasureTime frame
Duration of onset of anaesthesia and duration of postoperative analgesia and postoperative pain intensity following mandibular third molar surgery.Timepoint: Duration of onset of anaesthesia postoperative analgesia and postoperative pain intensity following mandibular third molar surgery.—

Secondary

MeasureTime frame
Time of onset of anaesthesia.Timepoint: Immediately after administration of Local anaesthesia;Duration of Soft tissue anaesthesia.Timepoint: Until return of normal sensation postoperatively.;Total postoperative analgesic consumption.Timepoint: within 48 hours after surgery.;Incidence of adverse effects or complications.Timepoint: During surgery and up to 7 days postoperatively.—

Countries

India

Contacts

Public ContactDR ESHITA JANA

HALDIA INSTITUTE OF DENTAL SCIENCES AND RESEARCH

soumyajitm94@gmail.com8967131632

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026