Health Condition 1: G939- Disorder of brain, unspecified
Conditions
Interventions
Intervention1: sugammadex: 2 mg/kg intravenously for moderate neuromuscular block (TOF 2/4) or 4 mg/kg for deeper block (TOF 0/4) single dose at the time of extubation [from stoppage of anesthetics to
Sponsors
AIIMS NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: Patients posted for supratentorial craniotomy for tumors less than 4 cm in size, with an expected surgical duration of less than 4 hours, anesthesia duration of less than 6 hours, and normal preoperative cognitive function (MMSE score 30/30)
Exclusion criteria
Exclusion criteria: Patients with ASA physical status III IV posted for emergency craniotomies, those with pre-existing neuromuscular disorders (such as myasthenia gravis or Guillain Barr syndrome), known allergy to the study drugs, pregnancy, or preoperative cognitive dysfunction (MMSE score <24) were excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative neurological assessment [time from administration of Sugammadex/ Neostigmine administration to first successful neurological assessment (defined as ability to follow commands, obey motor tasks, and reliable limb movement evaluation)] in minutes.Timepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve TOF ratio less than 0.9 during extubation Timepoint: extubation;Extubation time [from discontinuation of anesthetics to removal of endotracheal tube in minutes] Timepoint: extubation;Post operative airway complications (desaturation, obstruction, reintubation) Timepoint: in 24 hours;Postoperative hemodynamic changes during reversal [hypotension/ hypertension/bradycardia/tachycardia] Timepoint: in 24 hours;Surgeon satisfaction with early neurological evaluation. [5 point Likert scale] Timepoint: postop;Hospital length of stay Timepoint: hospital stay;Icu length of stayTimepoint: ICU stay | — |
Countries
India
Contacts
Public ContactIndu kapoor
AIIMS NEW DELHI
Outcome results
None listed