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A Study Comparing Two Materials Used to Treat Tooth Nerve Pain in Adult Molars: Injectable Platelet-Rich Fibrin (i-PRF) and MTA

Evaluating the Efficacy of Injectable Platelet Rich Fibrin (i-PRF) and Mineral Trioxide Aggregate as Pulpotomy Agents in Mature Mandibular Molars with Clinical Signs of Irreversible Pulpitis A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/113088
Enrollment
90
Registered
2026-06-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures Health Condition 2: K040- Pulpitis

Interventions

Intervention1: i-prf full pulpotomy: full pulpotomy on permanent molars using i-prf as pulpotomy agent Control Intervention1: mta full pulpotomy: full pulpotomy on permanent molars using mta as pulpot

Sponsors

DrAndrea Joseph
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults aged 18 to 50 years with fully developed roots ASA I to II health status and restorable teeth presenting with deep caries extending two thirds into dentin and symptoms of irreversible pulpitis lingering cold response prolonged pain without signs of necrosis or periapical pathology PAI less than or equal to 2 were included Only untreated teeth with no prior endodontic therapy and no radiographic evidence of resorption or calcification were considered with informed consent obtained

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pulp vitality maintenance, assessed through clinical and radiographic evaluations specific follow-up intervals (e.g., 3, 6, and 12 months). Success rate of the full pulpotomy procedure, defined by the absence of symptoms (pain, swelling) and normal periapical status. Timepoint: 3, 6, and 12 months

Secondary

MeasureTime frame
Patient-reported outcomes - quality of life assessments.Timepoint: 7 Days post operatively

Countries

India

Contacts

Public ContactAndrea Joseph

AIIMS VIJAYPUR JAMMU

saurabh.gupta@aiimsjammu.edu.in9896550674

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026