Health Condition 1: J22- Unspecified acute lower respiratory infection Health Condition 2: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: Collection of Nasopharyngeal Swabs.: The trial is of 48 months. There is no treatment intervention. All children under the age of 5 years, adults 16 to 60 years, and elderly people who
Sponsors
MSD India
Eligibility
Inclusion criteria
Inclusion criteria: The trial is of 48 months. There is no treatment intervention. All children under the age of 5 years, adults 16 to 60 years, and elderly people who give informed consents and who will develop acute lower respiratory tract infections or the dead person will be included in the study. These participants must be the resident of the 30 villages of Melghat tribal area during the data collection.The VHWs will collect nasopharyngeal swabs from the children and adults suffing from pneumonia and dead children and adults in the villages. The counsellors will collect nasopharyngeal swabs from children and adults suffering from pneumonia and admitted in hospitals. They will also collect nasopharyngeal swabs, NPS,from dead children and adults in hospitals.The nasopharyngeal swabs will be stored in MAHAN hospital in refrigerator under minus20 degree. NPS will be transported in viral media to National Institute of Virology Pune for viral analysis. It will be a daily process of collection of nasopharyngeal swab as per need.
Exclusion criteria
Exclusion criteria: All participants who will permanently migrate from study villages or who refused to give consent will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To obtain incidence of RSV LRTI in a cohort of infants and children under 5 and adults 16 to 60 years in 30 villages, over 3 years, and all newborns entering the cohort during the 4 years of the study. The RSV LRTI cases will be categorized using the WHO classification system. The genotype for each case will be determined using PCR.Timepoint: months: 6, 12,18,24,30, 36 months | — |
Secondary
| Measure | Time frame |
|---|---|
| A. The ratio of total number of each of the viruses positive cases to the total number of respiratory specimens tested during the study period from the catchment area will be obtained as a measure of burden of influenza, SARS CoV2 and hMPV related LRTI illness in the community. b. The incidence rate for each type of infection, influenza, SARS CoV2 and hMPV, will be obtained. c. The Influenza, SARS CoV2 and hMPV subgroup specific, Influenza A and B, and hMPV A and B, burden of illness will be evaluated and compared the severity based on subgroups. Timepoint: 36,42,48 months | — |
Countries
India
Contacts
Public ContactDr Ashish Satav
MAHAN trust
Outcome results
None listed