Faster Wake Up After Anesthesia The Role of Calcium with Neostigmine

Coadministration of calcium along with neostigmine for rapid reversal of neuromuscular blockade. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/113056

Enrollment

118

Registered

2026-06-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: Administration of calcium along with reversal: Administration of 5ml of 10% calcium along with 0.05 mg/kg Neostigmine for reversal of neuromuscular blockade. Control Intervention1: Admi

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II(20) Age 20-65 years Undergoing elective surgery in GA requiring muscle relaxation with non-depolarising neuromuscular blockers

Exclusion criteria

Exclusion criteria: Patients with known allergy or intolerance to neostigmine, glycopyrrolate or calcium compounds Known neuromuscular disorders Patients with renal or hepatic dysfunction Pregnancy or lactation Preexisting electrolyte imbalance (especially hypercalcemia or hypocalcemia)

Design outcomes

Primary

Measure	Time frame
To evaluate the effectiveness of coadministration of calcium with neostigmine in enhancing speed and quality of neuromuscular blockade reversal in patients undergoing elective surgery under general anaesthesia with non-depolarizing neuromuscular blocking agents.Timepoint: The evaluation will be done by using TOF at the time of reversal.	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Manurbhav Sapra

Rohilkhand Medical College and Hospital

dr.manurbhavsapra@gmail.com7206085010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026