Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Manipal College of Pharmaceutical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: VAC group (study cohort): Presence of diabetic foot wound, Meggit-Wagner classification 1-4, Treatment with VAC therapy or any other standard dressing care post debridement, Complete clinical data available Moist wound therapy group (reference cohort): Presence of diabetic foot wound, Meggit-Wagner classification 1-4, Treatment with VAC therapy or any other standard dressing care post debridement, Complete clinical data available
Exclusion criteria
Exclusion criteria: VAC group (study cohort): patients with compromised limb vascularity (absent vasculature and monophasic), Severe systemic diseases, malignancies, or haematological disorders, Malignant transformation of the ulcer, Active infection at other sites, Incomplete clinical data Moist wound therapy group (reference cohort): patients with compromised limb vascularity (absent vasculature and monophasic), Severe systemic diseases, malignancies, or hematological disorders, Malignant transformation of the ulcer, Active infection at other sites, Incomplete clinical data
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing parameters: wound area reduction, healing, granulation tissue formationTimepoint: during admission: consent, demographic details, wound severity scoring, wound photographs 1st follow up - wound severity scoring, wound photographs 2nd follow-up - wound photographs, wound closure method if any | — |
Secondary
| Measure | Time frame |
|---|---|
| Haematological inflammatory indices (NLR, MLR, PLR, SII, SIRI ratios) Timepoint: During admission: blood sample(samples collected as part of the standard operating procedure of the hospital ) 1st follow-up: blood sample, (samples collected as part of the standard operating procedure of the hospital ) 2nd follow-up - blood sample (samples collected as part of the standard operating procedure of the hospital);Biofilm assessmentTimepoint: During admission: wound swab from which bacterial isolates will be collected (samples collected as part of the standard operating procedure of the hospital) 1st follow-up: wound swab from which bacterial isolates will be collected (samples collected as part of the standard operating procedure of the hospital) | — |
Countries
India
Contacts
Public ContactDr Sonal Sekhar M
Manipal College of Pharmaceutical Sciences, MAHE, Manipal
Outcome results
None listed