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Effect of short term mild hyperventilation on optic nerve sheath diameter

Effect of short term mild hyperventilation on optic nerve sheath diameter in patients undergoing intracranial tumor surgeries under general anaesthesia- A prospective observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/113017
Enrollment
74
Registered
2026-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms

Interventions

Intervention1: Nil: Nil

Sponsors

Lokmanya Tilak Municipal Medical College and General Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.All patients undergoing craniotomy for intracranial tumour resection under general anaesthesia between age 18-60 years. 2.American Society of Anaesthesiologists Physical status (ASA-PS: I, II, III) 3.Patient willing to participate in our study.

Exclusion criteria

Exclusion criteria: 1. Optic nerve diseases (optic neuritis, optic nerve arachnoid cyst), 2. Ocular lesions such as orbital mass 3. Prior ophthalmic surgery 4. History of Orbital trauma 5. Pregnant females

Design outcomes

Primary

MeasureTime frame
To evaluate the change in the sonographic ONSD from before and after short-term controlled mild hyperventilation in neurosurgical patients undergoing surgery for intracranial tumours under general anaesthesia.Timepoint: Baseline parameters in supine. Baseline End tidal Carbon dioxide after 1 minute of preoxygenation. 5 minutes after achieving baseline ETCO2 post- intubation. 5 minutes after achieving ETCO2 value of 5 mmHg below the baseline value

Secondary

MeasureTime frame
1] To correlate the changes in ONSD with effects on haemodynamic parameters: heart rate, systolic blood pressure and mean arterial blood pressure. 2] To comparatively evaluate the ONSD changes between groups of compensated and decompensated increased ICP.Timepoint: Baseline parameters in supine. Baseline End tidal Carbon dioxide after 1 minute of preoxygenation. 5 minutes after achieving baseline ETCO2 post- intubation. 5 minutes after achieving ETCO2 value of 5 mmHg below the baseline value

Countries

India

Contacts

Public ContactDr. Sanjana Patil

Lokmanya Tilak Municipal Medical College and General Hospital

shalakagandhi@gmail.com9820625058

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026