FindTrial
Sign In

A study comparing two methods of pain control after knee replacement surgery: standard local pain injections alone and standard local pain injections with an additional nerve block.

Efficacy of intraoperative periarticular cocktail infiltration with added surgeon-administered adductor canal block versus periarticular cocktail infiltration alone in managing post-operative pain in patients undergoing Total knee arthroplasty : A double blinded randomised control trial - ACB-PAI TKA Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/113015
Enrollment
98
Registered
2026-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Group B (PAI + SACB): Patients will receive periarticular cocktail infiltration consisting of Magnesium sulphate 2 ml, Sodium bicarbonate 20 ml, Ropivacaine 20 ml (0.75%), Adrenaline 1

Sponsors

All India Institute of Medical Sciences Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Unilateral Total Knee Replacement patients Patients willing to provide informed consent

Exclusion criteria

Exclusion criteria: Allergy to study medications Extensive soft tissue release Severe varus deformity (HKA greater than10 ) Inflammatory arthritis Painful hip pathology Intraoperative fracture Previous steroid injection into knee Revision surgery Previous surgery around knee

Design outcomes

Primary

MeasureTime frame
Postoperative pain assessed using the Visual Analog Scale (VAS)Timepoint: 2 hours , 4 hours , 8 hours , 12 hours , 24 hours and 48 hours after the completion of surgery—

Secondary

MeasureTime frame
VAS Score at 2, 4, 8, 12 and 48 hours postoperatively.Timepoint: 2, 4, 8, 12, and 48 hours;Requirement of rescue analgesia (Intravenous Tramadol 100mg)Timepoint: ;Frequency of rescue analgesia during first 48 hours postoperativelyTimepoint: First 48 postoperative hours;Range of motion at 4, 12 24, 48 and 72 hours postoperativelyTimepoint: 4, 12, 24, 48, and 72 hours postoperatively;Time to breakthrough pain ( VAS greater than or equal to 5)Timepoint: ;Cumulative opioid consumptionduring first 48 postoperative hours.Timepoint:—

Countries

India

Contacts

Public ContactShubham Bhardwaj

All India Institute of Medical Sciences , Patna

drsudeepk@aiimspatna.org8544301681

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026