Health Condition 1: K053- Chronic periodontitis
Conditions
Interventions
Intervention1: Scaling and root planing with adjunctive oral probiotics: Scaling and root planing will be performed under standardized clinical conditions. Participants in the intervention group will
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 25 to 55 years diagnosed with Stage III periodontitis according to the 2018 AAP/EFP classification, with probing pocket depth of 5 mm or more in at least four sites and clinical attachment loss of 5 mm or more in at least two non-adjacent teeth. Participants must be systemically healthy or medically stable ASA I or II, have a minimum of 20 natural teeth, be willing to comply with study procedures and follow-up visits, and provide written informed consent.
Exclusion criteria
Exclusion criteria: History of periodontal therapy or professional prophylaxis within the last 6 months. Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months. Current or past smokers or tobacco users. Pregnant or lactating women. Known allergy or hypersensitivity to probiotics or any ingredient in the study formulation. Presence of systemic conditions known to affect periodontal disease progression, including uncontrolled diabetes, osteoporosis, immunodeficiency, or immunosuppressive therapy. Patients with aggressive periodontitis, gingival recession more than 3 mm as the primary lesion, or periodontitis associated with other syndromes. Non-compliance or inability to maintain oral hygiene instructions during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome has been revised to specify the main outcome used for sample size calculation. The revised primary outcome is change in clinical attachment level from baseline to 12 weeks. The time points have been revised as baseline and 12 weeks after intervention.Timepoint: Change in clinical attachment level following scaling and root planing with adjunctive oral probiotic therapy compared with scaling and root planing alone | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in probing pocket depthTimepoint: Baseline, 4 weeks, 8 weeks, and 12 weeks after intervention | — |
Countries
Nepal
Contacts
Public ContactShristi Kafle
Chitwan Medical College
Outcome results
None listed