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Management of gum loss in adults using tissue obtained from animals with and without blood derived proteins

Clinical evaluation of saline-hydrated versus advanced platelet-rich fibrin plus (A-PRF+) enriched xenogeneic pericardial membranes (XCM) in the management of gingival recession - Prospective comparative observational case series. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112968
Enrollment
10
Registered
2026-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K060- Gingival recession

Interventions

Intervention1: Intervention: Coronally Advanced Flap + Xenogeneic Pericardial Membrane: Coronally advanced flap (CAF) will be elevated, recipient site will be prepared. The recipient site dimensions

Sponsors

Sashank K
Lead Sponsor
Department of Periodontology SRM Dental College
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy subjects with an age range of 18 to 50 years 2. Individuals diagnosed with recession defects in maxillary anteriors and premolars (Cairo s RT1, RT2 classes of recession) 3. Sites with minimum depth of recession greater than or equal to 4 mm 4. Multiple adjoining recession involving lesser than or equal to 3 teeth

Exclusion criteria

Exclusion criteria: 1. Sites with probing pocket depth greater than or equal to 4 mm 2. Teeth with mobility and OR or associated with trauma from occlusion 3. Sites with dental caries and prosthetic restorations 4. Patient who exhibit unacceptable oral hygiene compliance during OR or after phase I therapy 5. Smokers 6. Pregnant and lactating women 7. Patient known allergic response with animal response with animal derived substances 8. Patients with known platelet disorders or using any medication that are known to interfere with platelet function 9. Patients with systemic conditions or disease influencing the course of periodontal disease and therapy

Design outcomes

Primary

MeasureTime frame
To assess and compare the changes in the recession height from baseline to 6 months between CAF+XCM and CAF+XCM+A-PRF plus groupsTimepoint: Baseline 3 months 6 months

Secondary

MeasureTime frame
To assess and compare the percentage of complete root coverage (CRC%) achieved at 6 months between CAF+XCM and CAF+XCM+A-PRF plus groupsTimepoint: 3, 6 months;To assess and compare the Root coverage esthetic scores following the treatment modalities (RES)Timepoint: 6 months;To assess and compare the patient perception regarding esthetics following the treatment modalities by using Visual Analogue Scale scores (VAS-E)Timepoint: 6 months

Countries

India

Contacts

Public ContactDr Anupama Tadepalli

SRM Dental College

anupamamds@gmail.com9677065517

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026