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Compare the outcome of mineral trioxide aggregate and platelet based materials used for direct pulp capping of cariously exposed permanent teeth in adult participants.

Efficacy of mineral trioxide aggregate, platelet rich fibrin and advanced platelet rich fibrin for direct pulp capping in adult permanent posterior teeth with carious pulp exposure - A randomized controlled trial. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112965
Enrollment
48
Registered
2026-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: Platelet Rich Fibrin: Direct pulp capping using Platelet Rich Fibrin Intervention2: Advanced Platelet Rich Fibrin: Direct pulp capping using Advanced Platelet Rich Fibrin Control Interv

Sponsors

Adyasha Pradhan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18 to 45 years. Permanent molars and premolars presenting carious pulp exposure. Tooth having no tenderness on percussion. Tooth diagnosed with reversible pulpitis. Positive pulp sensibility testing. Absence of periapical pathology. Patients who sign informd consent forms.

Exclusion criteria

Exclusion criteria: History of spontaneous pain. Teeth with irreversible pulpitis or necrotic pulp. Presence of periapical pathology. Negative response to pulp sensibility testing. Teeth with periodontal disease or inability to achieve proper isolation. Pregnant women. Patients with systemic diseases. Patients unwilling to provide informed consent.

Design outcomes

Primary

MeasureTime frame
Thickness of dentin bridge formation measured by CBCTTimepoint: 6 months after direct pulp capping procedure—

Secondary

MeasureTime frame
Pulp vitality assessed by sensibility testsTimepoint: 3,6,12 months after direct pulp capping procedure;Clinical success(absence of pain, tenderness, mobility)Timepoint: 3,6,12 months after direct pulp capping procedure;Radiographic success(absence of periapical pathology)Timepoint: 3,6,12 months after direct pulp capping procedure—

Countries

India

Contacts

Public ContactPriyanka Sarangi

SCB Dental College and Hospital, Cuttack

dr.subasish@gmail.com9937034576

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026