Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: E112- Type 2 diabetes mellitus with kidney complications
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Dr Susan Aishwarya S
Eligibility
Inclusion criteria
Inclusion criteria: Diabetic Nephropathy: Adults aged above 18 years, diagnosed with type 2 diabetes mellitus with a urine albumin-to-creatinine ratio of 30-300 mg per 24 h and estimated glomerular filtration rate less than 60 90 mL per min per 1.73 m2 Type 2 Diabetes:Adults aged above 18 years, diagnosed with type 2 diabetes mellitus with a urine albumin-to-creatinine ratio of less than 30 mg per 24h and estimated glomerular filtration rate more than 90 mL per min per 1.73 m2 Healthy human volunteers: Age and sex matched healthy individuals
Exclusion criteria
Exclusion criteria: DN, T2DM: Individuals with confirmed type 1 diabetes mellitus and presence of non-diabetic kidney diseases (glomerulonephritis, polycystic kidney disease), recent acute kidney injury within the last 3 months Healthy human volunteers: Any sign of microvascular complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of expression levels of NPHS1, NPHS2, ECM1, SOX9, GABP, LAMB2, COL4A1, SOST, EHD3, HAVCR1, and SPP1 in peripheral blood and urine samples between Type 2 Diabetes Mellitus (T2DM) patients, Diabetic Nephropathy (DN) patients, and healthy volunteers.Timepoint: 1 year to 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactDr Susan Aishwarya S
SRM Medical College Hospital and Research Centre
Outcome results
None listed