Comparing the efficacy of two topical sprays -Lignocaine (10%) and Ethyl chloride in reducing pain in patients who receive an intravenous access in the emergency department

To compare the efficacy of topical lignocaine(10%) vs vapocoolant spray(ethyl chloride) in reducing pain during intravenous cannulation in patients presenting to the Emergency department-a Randomized controlled trial - COOL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112921

Enrollment

140

Registered

2026-06-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G891- Acute pain, not elsewhere classified

Interventions

Intervention1: Vapocoolant spray(Ethyl chloride)-100 ml: Vapocoolant spray(Ethyl chloride)-Spraying will be done twice topically for 10 seconds ,then pain during intravenous cannulation will be docume

Eligibility

Inclusion criteria

Inclusion criteria: -Adult population of age 18-45 years presenting to the Emergency department -Adult population of 18-45 years who Consent for the study -Hemodynamically stable

Exclusion criteria

Exclusion criteria: Patients not consenting for the study,Population of age less than 18 years,Sick or unresponsive patients,Pregnant women,Patients allergic to lignocaine or ethyl chloride,Patients who have already received analgesics within the last 6 hours of ED arrival,Patients with distracting pain-Pain score more than or equal to seven at arrival in ED

Design outcomes

Primary

Measure	Time frame
Pain score by numerical rating scale during intravenous cannulation documented 1 minute after IV cannulationTimepoint: Pain score by numerical rating scale during intravenous cannulation documented 1 minute after IV cannulation	—

Secondary

Measure	Time frame
1.To study the vein visibility after the application of the 2 sprays 2.To compare the Adverse effects of the spray 3.To study the failure rate of IV access(need for more than 2 attempts)Timepoint: At the time of IV placement	—

Countries

India

Contacts

Public ContactPriya G

Christian medical college,Vellore

priyajyotsnav@gmail.com8903308084

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026