Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Deep Neuromuscular blockade: patient will be given deep neuromuscular blockade,
following induction, rocuronium infusion will be titrated to maintain post-tetanic
count (PTC) 1-2
Contro
Sponsors
Department of Anaesthesiology, AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients classified as American Society of Anesthesiologists (ASA) Physical Status I or II. 2. Patients scheduled for elective robot-assisted or laparoscopic surgery in the steep Trendelenburg position. 3. Pneumoperitoneum time to last longer than one hour or surgical time to last longer than 2 hours
Exclusion criteria
Exclusion criteria: 1. Patients who decline to provide informed consent for the study 2. Patients with known neurological diseases associated with raised or altered intracranial pressure(eg intracranial hypertension, pseudotumour cerebri, epilepsy, hydrocephalus, intracranial tumors, intracranial hemorrhage, traumatic brain injury) 3. Patients with ocular disorders such as glaucoma, optic neuritis that could affect optic nerve sheath diameter measurements. 4. Patients with Severe cardiovascular diseases such as unstable angina, recent MI, decompensated heart failure etc. 5. Patients with Severe pulmonary disease such as COPD grade iii-iv, severe restrictive diseases etc. 6. Patients with Morbid obesity (BMI more than 35 kg/m2) 7. Patients having Allergy or contraindication to study drugs 8. Patients with History of malignant hyperthermia or neuro-muscular disorders 9. Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of optic nerve sheath diameter(ONSD)Timepoint: At 60 min after creation of pneumoperitoneum | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamicsTimepoint: baseline, after induction, after pneumoperitoneum, in steep trendelenburg position, after desufflation;Quality of surgical fieldTimepoint: At the end of surgery;Recovery characteristicsTimepoint: Time to reversal Time to extubation;Postoperative neurological symptomsTimepoint: at 2, 6, 12, 24 hours postoperatively;Postoperative painTimepoint: 1,3,6 and 12 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Priyanka Gupta
All India Institute of Medical Sciences, RIshikesh
Outcome results
None listed