A Comparative Study of Cathepsin K Levels in Gum Fluid During Orthodontic Tooth Movement Using Friction and Frictionless Techniques

Evaluation of Cathepsin K Levels in Gingival Crevicular Fluid During Friction and Frictionless Mechanics of Orthodontic Tooth Movement A Comparative Study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112910

Enrollment

Registered

2026-06-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Friction mechanics: Participants will undergo canine retraction using sliding mechanics with NiTi closed-coil springs on 0.019 0.025-inch stainless steel archwires. A standardized for

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 15 20 years requiring fixed orthodontic treatment Healthy periodontium (no probing depth greater than 3 mm, no clinical attachment loss) Good oral hygiene and willingness to maintain it during study period (OHIS Score between 0 to 1.2) No previous orthodontic treatment in the study arch Patients willing to participate and sign informed consent

Exclusion criteria

Exclusion criteria: Systemic diseases or medications affecting bone/periodontal metabolism (e.g., bisphosphonates, steroids) Periodontal disease, active caries or extensive restorations on study teeth Smokers or tobacco users Pregnant and lactating women Recent antibiotic/anti inflammatory therapy (within last 3 months)

Design outcomes

Primary

Measure	Time frame
Comparison of Cathepsin K levels in gingival crevicular fluid (GCF) between friction and frictionless orthodontic mechanics, quantified by ELISA.Timepoint: Baseline (0 hour), 1 week, 1 month, and 3 months after activation of orthodontic force.	—

Secondary

Measure	Time frame
Temporal changes in Cathepsin K levels in gingival crevicular fluid within friction and frictionless mechanics groups and correlation of Cathepsin K levels with the rate of orthodontic tooth movement.Timepoint: Baseline (0 hour), 1 week, 1 month, and 3 months for Cathepsin K assessment baseline, 1 month, and 3 months for assessment of tooth movement.	—

Countries

India

Contacts

Public ContactDr Dhivyadharshini J

KSR institute of dental science and research

drrajamds@ksridsr.edu.in9677064440

Outcome results