Comparison of three materials amniotic membrane and collagen and platelet-rich fibrin for bone and gum healing in patients requiring dental implants

Comparative evaluation of amniotic membrane versus collagen versus platelet-rich fibrin for guided tissue regeneration in immediate implants: a randomized controlled clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112907

Enrollment

Registered

2026-06-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K084- Partial loss of teeth

Interventions

Intervention1: amniotic membrane: freshly prepared freeze dried human amniotic membrane Control Intervention1: PRF and collagen: platelet rich fibrin and collagen membrane

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients requiring immediate implant placement, using PRF, amniotic membrane, and collagen membrane with bone grafts. 2. Presence of adequate residual bone height. 3. Patients requiring soft and hard tissue augmentation. 4. Patients willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1. immunocompromised conditions that may impair wound healing or osseointegration. 2. Heavy smokers or tobacco users, due to their negative effect on soft tissue healing and bone regeneration. Patients with uncontrolled systemic diseases (e.g., uncontrolled diabetes, 3. Presence of acute infection, abscess, or severe periodontal disease at the implant site 4. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study will be the peri-implant bone changes at baseline and at 4 months Radiographic evaluation of peri-implant bone using CBCT to assess: Horizontal bone gain Vertical bone gain Crestal bone level changes Timepoint: The primary outcome of this study will be the peri-implant bone changes at baseline and at 4 months: Radiographic evaluation of peri-implant bone using CBCT to assess: Horizontal bone gain Vertical bone gain Crestal bone level changes	—

Measure

Time frame

The primary outcome of this study will be the peri-implant bone changes at baseline and at 4 months Radiographic evaluation of peri-implant bone using CBCT to assess: Horizontal bone gain Vertical bone gain Crestal bone level changes Timepoint: The primary outcome of this study will be the peri-implant bone changes at baseline and at 4 months: Radiographic evaluation of peri-implant bone using CBCT to assess: Horizontal bone gain Vertical bone gain Crestal bone level changes

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Secondary

Measure	Time frame
Soft tissue healing and early wound response Clinical Peri-implant parameters [Probing Depth; Bleeding on probing; Plaque Index]: Implant survival and success rate: To be assessed at the end of the 6-month follow-up Timepoint: Soft tissue healing and early wound response at 1st and 2nd week post operatively Clinical Peri-implant parameters [Probing Depth; Bleeding on probing; Plaque Index]: To be evaluated at 3 months and 6 months postoperatively. Implant survival and success rate: To be assessed at the end of the 6-month follow-up	—

Measure

Time frame

Soft tissue healing and early wound response Clinical Peri-implant parameters [Probing Depth; Bleeding on probing; Plaque Index]: Implant survival and success rate: To be assessed at the end of the 6-month follow-up Timepoint: Soft tissue healing and early wound response at 1st and 2nd week post operatively Clinical Peri-implant parameters [Probing Depth; Bleeding on probing; Plaque Index]: To be evaluated at 3 months and 6 months postoperatively. Implant survival and success rate: To be assessed at the end of the 6-month follow-up

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Countries

India

Contacts

Public ContactApurva PL

Saraswati Dental College and hospital

plapurva22@gmail.com09557625743

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026