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Identification of clinical subclasses and metabolomic changes in acute kidney injury following viper snake bite

Clinical subphenotyping and metabolomic profiling of acute kidney injury following viperid envenomation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112829
Enrollment
40
Registered
2026-06-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T630- Toxic effect of snake venom

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Kasturba Medical College and hospital, Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All confirmed viperid envenomation with evidence of VICC, Age more than 18 years, and written informed consent.

Exclusion criteria

Exclusion criteria: Pre-existing chronic kidney disease, Mixed or unidentified snake envenomation, Pregnant or lactating women and Paediatric patients.

Design outcomes

Primary

MeasureTime frame
Identification of 2 3 distinct SAKI subphenotypes with different risk profiles.Timepoint: Baseline- At hospital admission—

Secondary

MeasureTime frame
Characterisation of metabolic pathway perturbations (mitochondrial dysfunction vs. inflammatory vs. coagulopathic dominance) specific to each subphenotypeTimepoint: At baseline & 24 hours;Validated clinical prediction model integrating subphenotype class with early metabolomic data to predict KRT requirement & renal recovery.Timepoint: At baseline - hospital admission—

Countries

India

Contacts

Public ContactDr Ravindra Prabhu A

Kasturba Medical College

ravindra.prabhu@manipal.edu9448107771

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026