Effect of Zoledronate Gel on Dental Implant Stability and Bone Preservation A Randomized Clinical Study

Efficacy of 0.05 percent Zoledronate Gel on Implant Stability and Crestal Bone Levels in Partially Edentulous Sites A Randomized Controlled Clinical Study - ZOLE

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112804

Enrollment

Registered

2026-06-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: 0.05% Zoledronate gel in implant sites: Test group: 14 implant surfaces (first 3-4 threads) will be treated by 0.05% zoledronate gel coating. Control Intervention1: placebo gel: contro

Eligibility

Inclusion criteria

Inclusion criteria: Patients with single edentulous sites in either jaw. Healed extraction socket site more than or equal to 3 months. Primary implant stability more than or equal to 30Ncm.

Exclusion criteria

Exclusion criteria: Patients with systemic diseases. Smokers. Pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
To evaluate the implant stability using RFA and comparing ISQ values with and without 0.05% zoledronate gel. Timepoint: at baseline, 3 months and 6 months	—

Secondary

Measure	Time frame
To assess radiographic crestal bone levels around implant with and without 0.05% zoledronate gel.Timepoint: at baseline, 3 months and 6 months	—

Countries

India

Contacts

Public ContactDr S Vidya Sagar

Kamineni Institute of dental sciences

bhavanamekala06@gmail.com9493776363

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026