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A study comparing metformin and spironolactone, each used with minoxidil, for improving hair growth in women with female pattern hair loss

A Comparative Study of the Efficacy and Safety of Oral Metformin Plus Topical Minoxidil Versus Oral Spironolactone Plus Topical Minoxidil in Female Pattern Hair Loss (FPHL) - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112776
Enrollment
74
Registered
2026-06-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L648- Other androgenic alopecia

Interventions

Intervention1: Oral Metformin Plus Topical Minoxidil: Oral Metformin 500 milligram twice daily plus Topical Minoxidil 2 percent solution applied twice daily for 3 months Control Intervention1: Oral Sp

Sponsors

Vilasrao Deshmukh Government Medical College, Latur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Females aged 18 45 years Clinical diagnosis of FPHL confirmed by trichoscopy Sinclair/Ludwig grade I III Willingness to comply with treatment Written informed consent

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Uncontrolled diabetes Renal dysfunction Hepatic dysfunction Cardiovascular disease Concurrent antiandrogen therapy Concurrent insulin sensitizers Drug hypersensitivity

Design outcomes

Primary

MeasureTime frame
Hair Density Measured using phototrichogram Unit: Number of hairs/cm Timepoint: Baseline and Month 3—

Secondary

MeasureTime frame
Hair shaft thickness Terminal:vellus hair ratio Global photographic assessment DLQI score HOMA-IR Fasting insulin Serum testosterone SHBG Adverse eventsTimepoint: 1 month, 2 months, 3 months—

Countries

India

Contacts

Public ContactDr Sakshi VinodKumar Jain

Vilasrao Deshmukh Government Medical College, Latur

dr.ajayovhal@gmail.com9422649911

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026