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A Study between two drugs mannitol and 3% NS to see which have decreased brain pressure during laproscopy surgery

Comparison of the effect of 20% Mannitol and 3 % Hypertonic saline for prevention of the raised intracranial pressure by evaluating Optic nerve sheath diameter (ONSD) during Laparoscopic surgery in Trendelenburg position - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112720
Enrollment
98
Registered
2026-06-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Effect of 20% Mannitol in decreasing ICP as measured by optic nerve sheath diameter : Mannitol is administered immediately after creation of pneumoperitoneum. ONSD is measured at induc

Sponsors

Dr Bibha Kumari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: BMI between 20 to 30kg/m2 ASA GRADE - I to III Patients with normal ocular anatomy and physiology. MPG class 1 to 3

Exclusion criteria

Exclusion criteria: History of Hypertension Past history of any Neurological disease.

Design outcomes

Secondary

MeasureTime frame
To evaluate the hemodynamic effects of change in ICP during Laproscopic surgery in steep Trendelenburg position. 2- To study about nausea, vomiting or any other side effects . Timepoint: Every 5 minutes from induction till 1 hour of extubation—

Primary

MeasureTime frame
To evaluate the efficacy of 20% Mannitol and 3% Hypertonic saline in decreasing Intracranial pressure during Laproscopic surgery by Ultrasonographic measurement of Optic Nerve Sheath Diameter (ONSD) in Trendelenburg position Timepoint: T1 - Before induction of anesthesia T2 - 5mins after induction T3 - 5mins after pneumoperitoneum T4 - 10mins after drug intervention T5 - Every 30 mins after drug intervention T6 - Within 1 hour after extubation—

Countries

India

Contacts

Public ContactDr Sarthak Misra

Indira Gandhi Institute of medical sciences

DRSARTHAKMISRA2021@GMAIL.COM08210641979

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026