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A study comparing three root canal cleaning methods and their effect on pain and inflammation after treatment in patients with tooth nerve infection.

Conventional versus conservative rotary instrumentation on expression of inflammatory mediators (Substance P, PGE2, CRP) and postoperative pain in mandibular molars with asymptomatic irreversible pulpitis: A Single blinded, three arm parallel, randomised controlled trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112676
Enrollment
48
Registered
2026-06-15
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Conventional and conservative rotary instrumentation in mandibular molars with asymptomatic irreversible pulpitis: Participants will undergo nonsurgical root canal treatment using one o

Sponsors

Periyasamy R
Lead Sponsor
Department of Health Research
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 50 years who presented with no systemic disease (American Society of Anesthesiology class I) and required nonsurgical root canal treatment, Vital Mandibular 1st and 2nd molar, Diagnosis of asymptomatic irreversible pulpitis in a mandibular molar tooth with normal root canal anatomy, Patients who have given consent and are fully ready for subsequent follow-up visits and assessment

Exclusion criteria

Exclusion criteria: Patients with immunosuppressive/systemic diseases, prolong analgesics and antibiotics, pregnant/lactating mothers, Cracked or unrestorable teeth, teeth with periodontal probing depths 4 mm or more, incomplete root formation, Periapical index (PAI) score not more than 4, Tooth with aberrant root canal anatomy, dilacerated, incomplete root formation, Sinus tract, calcified canals and other root deformities.

Design outcomes

Primary

MeasureTime frame
Clinical Outcome Comparison of stimulation of inflammatory biomarkers on the three arms of treatment, Comparison of pain perception on the three arms of treatment. Removal of infected and necrotic pulp. Timepoint: Baseline, 24 hrs and 7 days

Secondary

MeasureTime frame
Patient-centred Outcome: Healing of the periapical infection & restoration of carious tooth form & function.Timepoint: Baseline, 24 hrs & 7 days

Countries

India

Contacts

Public ContactPERIYASAMY R

All India Institute of Medical Sciences, Bathinda

drtarunkumarsingh@gmail.com09560627466

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026