A study comparing dexmedetomidine and lidocaine for reducing coughing during extubation after laparoscopic surgery.

Comparison of Effect of Intratracheal Dexmedetomidine with Intratracheal Lidocaine on Attenuation of Peri-Extubation Cough in Adult Patients Undergoing Elective Laparoscopic Surgeries- A Prospective, Randomised, Controlled, Single Blinded Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112644

Enrollment

120

Registered

2026-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K36- Other appendicitis

Interventions

Intervention1: Intratracheal dexmedetomidine: Intratracheal administration of 20mcg dexmedetomidine via endotracheal tube. Intervention2: Intratracheal lidocaine: Intratracheal administration of 2ml o

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiology Physical Status I II patients of either gender between age 18- 60 years. Patients undergoing laparoscopic surgeries under general anaesthesia and which require oral intubation.

Exclusion criteria

Exclusion criteria: Patients with recent upper respiratory tract infection, laryngeal or tracheal pathology Patients with heart disorders bradycardia heart block sick sinus syndrome coronary heart disease Patients allergic to local anesthetic Patients who are planned to received intravenous dexmedetomidine intraoperatively Patients needing nasogastric tube insertion Difficult airways needing more than two attempts of laryngoscopy and intubation

Design outcomes

Primary

Measure	Time frame
Frequency and severity of peri extubation cough assessed using validated cough grading scaleTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating	—

Secondary

Measure	Time frame
BronchospasmTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating;LaryngospasmTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating;BradycardiaTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating	—

Measure

Time frame

BronchospasmTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating;LaryngospasmTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating;BradycardiaTimepoint: Baseline before study drug administration 5 min after study drug At extubation 1 min post extubating 3 min post extubating 5 min post extubating

—

Countries

India

Contacts

Public ContactSribhashyam Vasudha

JSS Medical College and Hopsital

darshinis@jssuni.edu.in7702184188

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026