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Study of factors affecting recovery and survival in patients with severe COPD requiring mask based breathing support in hospital

Prevalence and risk factors of non invasive ventilation failure and thirty day mortality in acute exacerbation of chronic obstructive pulmonary disease requiring NIV - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112634
Enrollment
190
Registered
2026-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J42- Unspecified chronic bronchitis

Interventions

Intervention1: Nil: Nil Intervention2: NIL: NIL

Sponsors

Office of Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults aged more than or equal to 18 years admitted with acute exacerbation of chronic obstructive pulmonary disease requiring noninvasive ventilation will be included by consecutive sampling after written informed consent.

Exclusion criteria

Exclusion criteria: nil

Design outcomes

Primary

MeasureTime frame
Non invasive ventilation failureTimepoint: During the index hospital admission, from initiation of NIV until hospital discharge—

Secondary

MeasureTime frame
Prognostic performance of admission NLR & NPAR for predicting NIV failure, in-hospital mortality & 30-day mortality, compared with DECAF score, HACOR score, CRP & procalcitonin.Timepoint: Biomarkers measured at admission Outcomes assessed during hospital admission & at 30 days;Association between admission NLR & NIV weaning failure.Timepoint: NLR measured at admission NIV weaning outcome assessed during hospital admissioN;Association of NLR & NPAR with disease severity as assessed by DECAF & HACOR scores.Timepoint: At admission;Association of NLR & NPAR with duration of NIV use, hospital length of stay, ICU transfer, discharge on oxygen therapy, & discharge on NIV support.Timepoint: During hospital admission & at hospital discharge;To determine the optimal threshold values of NLR & NPAR for predicting noninvasive ventilation (NIV) weaning failure & in-hospital & 30-day mortality.Timepoint: Biomarkers measured at admission Outcomes assessed during hospital admission & at 30 days—

Countries

India

Contacts

Public ContactGautam Prem

Christian Medical College,Vellore

barneyisaac98@cmcvellore.ac.in9606133993

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026