Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Octreotide: Initial bolus 50mcg followed by continuous infusion 50mcg/hour for 72 hours
Control Intervention1: Terlipressin: 2mg IV stat followed by 1mg 6 hourly for 72 hours
Sponsors
Amrita Jha
Eligibility
Inclusion criteria
Inclusion criteria: Age more than 18 years with UGI bleed and undergoing UGIE CTP A and B UGIB attributable to acute esophageal variceal bleeding Ability to provide informed consent
Exclusion criteria
Exclusion criteria: Non-variceal upper GI bleeding, Isolated Gastric and Ectopic varices Uncontrolled shock despite resuscitation Previous TIPS or surgical shunt Ischemic heart disease or severe peripheral vascular disease Known allergy to study drugs Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess rates of rebleedingTimepoint: Within five and forty two days post EVL | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare mortality ratesTimepoint: At six weeks & three months post EVL;Need for rescue therapyTimepoint: During hospital stay;Need for repeat endoscopic intervention Timepoint: During hospital stay;To document & compare drug-related adverse events in both groupsTimepoint: During hospital stay;To assess differences in length of hospital stay Timepoint: At the end of hospital stay | — |
Countries
India
Contacts
Public ContactVinod Kumar
Institute of Medical Sciences, Banaras Hindu University
Outcome results
None listed