Comparison of two different ways of how we reduce and stop the respiratory support called HHHFNC therapy i e heated humidified high flow nasal cannula therapy in children who are recovering from lung infections like pneumonia or bronchiolitis

Comparison of direct flow weaning strategy with step-wise flow weaning strategy of heated humidified high flow therapy in children with bronchiolitis and pneumonia, an open-label randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112602

Enrollment

210

Registered

2026-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J189- Pneumonia, unspecified organism

Interventions

Intervention1: Direct flow reduction strategy: Reduction in flow from the initial setting to 2 litres per minute once FIO2 is 21 percent and is stable for 4 hours Control Intervention1: Step wise flow

Eligibility

Inclusion criteria

Inclusion criteria: Children admitted to Emergency or PICU aged 1month to 5 years with a clinical diagnosis of bronchiolitis or pneumonia and HFNC required for more than 12 hours

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Time taken to wean the heated humidified high flow therapyTimepoint: The time point varies depending on the recovery from the illness Cannot specify	—

Secondary

Measure	Time frame
Rates of failure of weaning strategiesTimepoint: The time point varies depending on the recovery from the illness Cannot specify;Length of stay in the hsopital in daysTimepoint: The time point varies depending on the recovery from the illness Cannot specify;MortalityTimepoint: The time point varies depending on the recovery from the illness Cannot specify	—

Countries

India

Contacts

Public ContactVibhu V

All India Institute Of Medical Sciences, Kalyani

niladri.peds@aiimskalyani.edu.in9432879603

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026