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A Study Comparing Two Types of PRP Injections for Slip Disc Treatment

A Study on treatment efficacy of intradiscal autologous injection of platelet rich plasma vs leucocyte poor platelet rich plasma in lumbar inter vertebral disc prolapse , A randomized control trial - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112583
Enrollment
40
Registered
2026-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: platelet rich plasma: 20 ml of own blood centrifugation to get a platelet rich plasma for 15 to 20 minutes Control Intervention1: leucocytes poor platelet rich plasma: 20 ml of own blo

Sponsors

Jipmer
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 to 50 years , Refractory low back pain persisting for 3-12 weeks ,lumbar disc protrusion or extrusion at single level , Maintained intervertebral disk height of at least 50 percentage on MRI , Disc protrusion or extrusion seen on MRI corresponding to clinical findings

Exclusion criteria

Exclusion criteria: Spinal dysmorphism ,With neurological deficit ,Sequestered disc fragments ,previous surgical intervention for spine ,Facet arthropathy ,Sacroiliac joint pain ,Traumatic spine injury ,Known bleeding disorder or on anticoagulants or antiplatelet drugs ,Pregnancy ,Psychiatric condition ,Peripheral neuropathy- diabetes with peripheral neuropathy, leprosy, syphilis ,Tumors Infective discitis

Design outcomes

Primary

MeasureTime frame
The intervention involves a single intradiscal injection of autologous PRP, while the comparison group receives an intradiscal injection of Leucocyte poor PRP. The primary outcomes will be measured using the Visual Analog Scale for pain and the Functional Rating Index for disability, to assess improvements in pain and functional status following treatment.Timepoint: 6 months—

Secondary

MeasureTime frame
In individuals with lumbar intervertebral disc prolapse receiving intradiscal injections of platelet-rich plasma versus leucocyte-poor PRP, a follow up MRI will be conducted at the 6th month post-injection to assess and compare morphologic changes in the intervertebral disc between the two groups.Timepoint: 6 months—

Countries

India

Contacts

Public ContactSuryanarayanan A

Jipmer hospital

prabublue@gmail.com8220722782

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026