comparison of herbal treatment with injection treatment in oral submucous fibrosis

Comparative assessment of topical pippali oral paste with intralesional injections in Oral submucous fibrosis A randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112578

Enrollment

Registered

2026-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis

Interventions

Intervention1: Topical Pippali oral paste: Natural product PIppali mixed with Licorice and honey Control Intervention1: Intralesional corticosteroid injection: Intralesional injection of Hyaluronidase

Eligibility

Inclusion criteria

Inclusion criteria: Patients with clinical and functional stage 2 or 3 OSMF according to classification by More CB et al in 2011. Patients willing to participate in the study.

Exclusion criteria

Exclusion criteria: Patients who have undergone previous treatment for the disease. pregnant and lactating females. Patients with other premalignant conditions. Patients with other conditions which can affect mouth opening. patients with uncontrolled systemic illness.

Design outcomes

Primary

Measure	Time frame
Increase in the inter incisal mouth openingTimepoint: 3 months	—

Secondary

Measure	Time frame
reduction in burning sensationTimepoint: 3 months	—

Countries

India

Contacts

Public ContactHaritha KV

Goa Dental College and Hospital

khoratemanisha@gmail.com9823213773

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026