A study to compare intraperitoneal instillation between Ropivacaine with Dexmedetomidine and Ropivacaine with Clonidine for postoperative pain relief in patients undergoing Total Laparoscopic Hysterectomy

Intraperitoneal Instillation of Ropivacaine with Dexmedetomidine versus Ropivacaine with Clonidine for Postoperative Analgesia in Patients Undergoing Total Laparoscopic Hysterectomy: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112572

Enrollment

Registered

2026-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intraperitoneal Ropivacaine with Clonidine: Intraperitoneal instillation of Ropivacaine 0.25% (28 mL) with Clonidine 1 g/kg diluted in normal saline to 2 mL (total volume 30 mL) given

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical Status I and II Scheduled for elective TLH Body mass index (BMI) less than or equal to 30 kg per meter square Ability to understand and use the Visual Analog Scale (VAS) Willingness to participate and provide written informed consent

Exclusion criteria

Exclusion criteria: Refusal to participate Known allergy or hypersensitivity to ropivacaine, dexmedetomidine, clonidine, or opioids ASA III or IV patients Chronic pain conditions or long-term analgesic/opioid use Severe hepatic, renal, cardiac, or respiratory disease Coagulation disorders or infection at surgical site Pregnancy or lactation Conversion to open surgery (laparotomy)

Design outcomes

Primary

Measure	Time frame
To compare postoperative analgesic efficacy between Ropivacaine with Dexmedetomidine and Ropivacaine with Clonidine using: VAS AUC (0 24 hours) Time to first rescue analgesic Total 24-hour analgesic requirement Timepoint: Time of extubation will be taken as 0 hours. Above points will be observed at 0 , 0.5, 1, 2, 4, 8, 12, and 24 hours	—

Secondary

Measure	Time frame
To compare: Haemodynamic parameters (HR, SBP, DBP, MAP) Sedation scores (Ramsay) Incidence of PONV Shoulder-tip pain Adverse effects within 24 hours Timepoint: Time of extubation will be taken as 0 hours. Above points will be observed at 0 ,0.5, 1, 2, 4, 8, 12, and 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDr Tilka Ghate

NKP Salve Institute Of Medical Sciences And Research Centre And Lata Mangeshkar Hospital

heenapahuja15@yahoo.com9823188160

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026