Study to compare the effectiveness of two drugs named dexmedetomidine and magnesium sulphate mixed with a local anaesthetic agent in a procedure called thoracic paravertebral block in decreasing post operative pain in patients who are undergoing surgery for breast cancer

Comparison of efficacy of magnesium sulphate and dexmedetomidine as adjuvants to ropivacaine in ultrasound guided thoracic paravertebral block for post operative analgesia in patients undergoing modified radical mastectomy under general anaesthesia. - nil

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112566

Enrollment

100

Registered

2026-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50- Malignant neoplasm of breast

Interventions

Intervention1: Ultrasound guided thoracic paravertebral block with ropivacaine + dexmedetomidine mixture: After obtaining informed consent, all patients will receive standard ASA monitoring. Under str

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 30-65 years of age of female sex, belonging to ASA II ,III undergoing elective modified radical mastectomy surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with known hypersensitivity to study drugs. 2. Patients on medication for chronic pain. 3. Patients with coagulopathies and on anti-coagulant therapy. 4. Patients with psychiatric and neurological disorders 5. Patients having deformities or disorders of spine

Design outcomes

Primary

Measure	Time frame
To compare duration of analgesia between two groups. Group A (n=50): will receive preoperative USG thoracic paravertebral block with 20ml (0.25% Ropivacaine 19ml + MgSO4 250mg diluted in 1ml normal saline) Group B (n=50): will receive preoperative USG thoracic paravertebral block with 20ml (0.25% Ropivacaine 19ml + Dexmedetomidine 50mcgs diluted in 1ml normal saline) Timepoint: immediate post-op,2 hrs,4 hrs, 6 hrs, 12 hrs, 18hrs,24hrs	—

Measure

Time frame

To compare duration of analgesia between two groups. Group A (n=50): will receive preoperative USG thoracic paravertebral block with 20ml (0.25% Ropivacaine 19ml + MgSO4 250mg diluted in 1ml normal saline) Group B (n=50): will receive preoperative USG thoracic paravertebral block with 20ml (0.25% Ropivacaine 19ml + Dexmedetomidine 50mcgs diluted in 1ml normal saline) Timepoint: immediate post-op,2 hrs,4 hrs, 6 hrs, 12 hrs, 18hrs,24hrs

—

Secondary

Measure	Time frame
1. To compare total rescue analgesic consumption in 24hours between two groups. 2. To compare the hemodynamic changes between two groups 3. To compare the level of sedation between two groups 4. To compare adverse effects between two groups.Timepoint: immediate post-op,2 hrs,4 hrs, 6 hrs, 12 hrs, 18hrs,24hrs	—

Countries

India

Contacts

Public ContactDr K ANITHA

Government Medical College, Kadapa

anithakalavagunta@gmail.com7093897878

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026