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Comparing the Effectiveness of Two Medicines in Controlling Pain After a Single-Sitting Root Canal Procedure in Dental Patients: A Randomized Controlled Trial

Comparative Evaluation of Premedication with Ketorolac and Dexamethasone on Postendodontic Pain After Single Visit Root Canal Treatment - A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112536
Enrollment
30
Registered
2026-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Ketorolac: Patients will receive oral Ketorolac as premedication before single visit root canal treatment Postendodontic pain will be assessed using a Visual Analog Scale at predetermin

Sponsors

Department of conservative dentistry and endodontics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients American Society of Anesthesiologists class Single rooted tooth diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis Teeth will be included if they have moderate sharp spontaneous pain preoperative visual analogue scale score less than 4 Ability to read and comprehend the visual analogue scale sheets and informed consent Teeth that demonstrated tenderness upon percussion, along with a positive reaction to electric pulp testing and a prolonged response exceeding 10 seconds to cold testing The teeth with periapical changes in radiographs Periapical Index less than 2 Having no history of painkillers administrated with 12 hours before procedure

Exclusion criteria

Exclusion criteria: Teeth with crown/root fractures Acute or chronic apical abscess Pulp necrosis Compromised periodontium and open apices Allergic to NSAIDs Pregnant or lactating women Previously treated/initiated root canal treatment Retreatment cases

Design outcomes

Primary

MeasureTime frame
Postendodontic pain intensity following single visit root canal treatment measured using Visual Analog Scale VASTimepoint: 6 12 24 48 and 72 hours after Root Canal Treatment

Secondary

MeasureTime frame
Comparison of the effectiveness of Ketorolac and Dexamethasone in reducing postendodontic painTimepoint: 6 12 24 48 and 72 hours after Root Canal Treatment

Countries

India

Contacts

Public ContactDr Abhay Wasu

Ranjeet Deshmukh Dental College And Research Center Nagpur

badole_g15@yahoo.co.in9665410655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026