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Comparison of Two Doses of Intranasal Dexmedetomidine on Heart Rate and Blood Pressure Changes in Patients Undergoing Brain Surgery: A Randomized Double-Blind Study

EFFECTS OF TWO DIFFERENT DOSE S OF INTRA NASAL DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSES IN PATIENTS UNDERGOING CRANIOTOMY:A RANDOMISED DOUBLE BLIND STUDY - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112533
Enrollment
96
Registered
2026-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Dr jaswant singh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of ASA Physical status I & II 2. Age 18 to 65 years of either gender 3. Posted for craniotomy requiring the skull pin application

Exclusion criteria

Exclusion criteria: Known hypersensitivity to study drug. CSF Rhinorrhea. Patient with heart block. Patient receiving any kind of pre procedural analgesics in last 24 hours. Drug altering hemodynamic responses. Surgery in any position other than supine. Morbid obesity

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the effect of two different doses of intranasal dexmedetomidine on hemodynamic responses at the time of skull pin in application Timepoint: 3 months—

Secondary

MeasureTime frame
To compare between the two groups: Requirement of total analgesics & anaesthetic agents during the surgeryTimepoint: 3 months—

Countries

India

Contacts

Public Contactjaswant singh

Geetanjali Medical College and Hospital

drneelesh1106@gmail.com8890663427

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026