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Time taken for muscles to recover and function normally after stopping a continuous infusion of a drug that blocks muscular Function

Time to Neuromuscular Recovery following Discontinuation of Cisatracurium infusion in Adult Patients undergoing Elective Laparoscopic Colorectal or Robot assisted laparoscopic Abdominal Surgeries. A Prospective Observational Study - TIMECIS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112496
Enrollment
76
Registered
2026-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Christian Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged 18 65 years. ASA physical status I,II & III. Patients scheduled for Elective Laparoscopic Colorectal and Robot assisted Laparoscopic Abdominal surgeries

Exclusion criteria

Exclusion criteria: Known neuromuscular disorders Severe hepatic or renal impairment Pregnancy or lactation. Known hypersensitivity to neuromuscular blocking agents. Patients on medications affecting neuromuscular transmission Body Mass Index greater than 35

Design outcomes

Primary

MeasureTime frame
To determine the mean time required to attain TOF ratio greater than or equal to 0.9 after stopping Cisatracurium infusionTimepoint: TOF will be assessed every 10 minutes after stopping Cisatracurium Infusion—

Secondary

MeasureTime frame
To determine the time required to attain a TOF ratio 0.9 after administration of reversal agentsTimepoint: Reversal agents will be administered after TOF attains 0.7. After that every 10 minutes we assess TOF till it reaches 0.9; To quantify intraoperative opioid requirements & analyze their association with depth of neuromuscular blockade & recovery profile.Timepoint: Opioids will be administered intraoperatively based on Hemodynamic changes due to painful stimulus; To measure the minimum alveolar concentration (MAC) during maintenance anesthesia & study its relationship with neuromuscular blockade depthTimepoint: Intraoperative Mean Alveolar Concentration of Inhalational Agents will be measures every 30 minutes after starting Cisatracurium infusion till the infusion will be discontinued; To quantify intraoperative Neuromuscular Bolus requirementsTimepoint: Neuromuscular Bolus will be administered of the usual infusion dosage is not enough for maintaining T1 value equals to 10 percentage—

Countries

India

Contacts

Public ContactJoel Koil Raj

Senior Professor

chitraanaes73@gmail.com09965565990

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026