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Comparison between intravenous Magnesium Sulphate and Dexmedetomidine in reducing hemodynamic responses during laryngoscopy and endotracheal intubation

Comparing the efficacy of intravenous Magnesium Sulphate and Dexmedetomidine in reducing the haemodynamic stress response during laryngoscopy and endotracheal intubation : A Prospective randomised study at SMS Medical College, Jaipur - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112447
Enrollment
60
Registered
2026-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Control Intervention1: intravenous Magnesium Sulphate: Inj 50% Magnesium Sulphate 25mg/kg diluted in 10 ml Normal Saline and given slow over 10 minutes, before induction Contr

Sponsors

Sawai Man Singh Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Scheduled for elective surgery, under general anaesthesia. 2. Patients belonging to American Society of Anaesthesiologist (ASA) physical status grade I and II. 3. Patients willing to give written informed consent. 4. Patients of either sex. 5. Age Groups 18 to 60 years. 6. Weighing 40 to 70 kg.

Exclusion criteria

Exclusion criteria: 1. Patients having history of allergy to anaesthestic agents used in study. 2. Patients with pulmonary hypertension, sinus bradycardia, heart failure and cardiogenic shock. 3. Patients with anticipated difficult intubation i.e Mallampati class 3 or more, restricted neck movement or restricted mouth opening. 4. Pregnant patients and lactating mothers. 5. Patients having history of convulsion. 6. Patients having BMI more than 35 (Morbid Obesity). 7. Hepatic or Renal Dysfunction. 8. History of drug abuse.

Design outcomes

Primary

MeasureTime frame
1. Mean of Heart rate (HR) 2. Mean of Systolic blood pressure (SBP) 3. Mean of Diastolic blood pressure (DBP) 4. Mean of Mean arterial blood pressure (MAP) 5. Mean of Rate pressure product (RPP) 6. Proportion of patients with Side Effects (if any). 7. Mean of Ramsay sedation score.Timepoint: HR, SBP, DBP, MAP, SpO2 at baseline, before study drug is given,1 , 3 ,5, 10, 15 min after the study drug is given—

Secondary

MeasureTime frame
nilTimepoint: nil—

Countries

India

Contacts

Public ContactDr Hemani Yadav

Sawai Man Singh Medical College, Jaipur

rajnimathur@hotmail.com9829357194

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026