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Effectiveness of Bone Graft Alone Versus Bone Graft Combined With Growth Factor in Treating Bone Loss Around Teeth

Comparative evaluation of efficacy of Freeze Dried Bone Allograft (FDBA) with recombinant human Platelet Derived Growth Factor (rh-PDGF) and Freeze Dried Bone Allograft (FDBA) alone in the treatment of human Intrabony periodontal defects - A Randomized Controlled Clinico-Radiographic Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/06/112414
Enrollment
20
Registered
2026-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: K053- Chronic periodontitis

Interventions

Intervention1: Group A FDBA with rh PDGF group: Ten patients with angular intrabony periodontal defect follow up at 0,3 months and 6 months Control Intervention1: Group B FDBA Group: Ten patients with

Sponsors

Dr Abhishek Sharma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Age group ranging from 25-50 years 2 Good level of oral hygiene(plaque index less than or equal to 1) 3 Subjects of either sex having Generalised Chronic Periodontitis 4 Subjects who are systemically healthy with no contraindication to periodontal surgery 5 Presence of PD (more than equal to 5mm) in relation to with radiographic evidence of angular bone loss 6 Compliant subjects

Exclusion criteria

Exclusion criteria: 1 Subjects with any systemic disease 2 Individuals having any deleterious habits, such as smoking or tobacco chewing 3 Subjects allergic or sensitive to any medication or any ingredient of the test- material 4 Subjects showing unacceptable oral hygiene compliance during/ after phase -I therapy 5 Pregnant or lactating females 6 Subjects who have undergone any periodontal surgery in the past 6 months 7 Subjects prescribed with steroidal therapy/chemotherapy/Radiotherapy 8 Non compliant subjects

Design outcomes

Primary

MeasureTime frame
Gain in Bone fill using radio graph pre and post surgery Timepoint: 0,3,6 months.

Secondary

MeasureTime frame
Gain In Relative attachment Level in intrabony defects Timepoint: 0,3 and 6 Months;Reduction in Pocket Probing Depth in intrabony defectsTimepoint: 0,3,6 Months

Countries

India

Contacts

Public ContactDr Mehvish Saleem

Subharti Dental College and Hospital, Swami Vivekanand subharti university

mehvishkhan1087@gmail.com8267011559

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026