FindTrial
Sign In

Predictive Performance of the ROX Index for High-Flow Nasal Cannula Oxygen Therapy Failure in Chronic Liver Disease patients with Sepsis and Septic Shock: A Prospective Observational Study

Predictive Performance of the ROX Index (Respiratory Rate-Oxygenation Index) for High-Flow Nasal Cannula Oxygen Therapy Failure in Chronic Liver Disease patients with Sepsis and Septic Shock: A Prospective Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112408
Enrollment
60
Registered
2026-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K74- Fibrosis and cirrhosis of liver

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Diagnosed chronic liver disease patients with sepsis/septic shock (Sepsis-3 definition) and acute hypoxemic respiratory failure requiring HFNC 2.Duration of illness less than 1 week

Exclusion criteria

Exclusion criteria: 1.Immediate need for intubation 2.Do-not-intubate status 3.Chronic home oxygen therapy 4.Hypercapnic respiratory failure as primary indication 5.Severe Hepatopulmonary syndrome 6. Grade 3 and 4 Hepatic Encephalopathy

Design outcomes

Primary

MeasureTime frame
Predictive performance of ROX index for HFNC failure within 48 hours after HFNC initiationTimepoint: 2, 6, 12 and 48 hours—

Secondary

MeasureTime frame
Independent predictors of HFNC failureTimepoint: 2, 6, 12, 48 Hours—

Countries

India

Contacts

Public ContactNavpreet Bhatia

Department of Anaesthesia, Institute of Liver and Biliary Sciences

sonamravigupta1@gmail.com8130657296

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026