None listed
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Sponsors
KLE Academy for Higher Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Tobacco Chewers belonging to the following 3 Groups Group 1 - Individuals with histopathologically confirmed Oral Squamous Cell Carcinoma (not previously treated for the condition) , n=37 Group 2 - Individuals with histopathologically confirmed Oral Leukoplakia and not previously treated for the condition , n=37 Group 3 - Apparently Healthy , Age and Sex matched individuals with normal Oral Mucosa , n=37
Exclusion criteria
Exclusion criteria: Non - Tobacco chewers Individuals with secondary Oral Cancer or any other Systemic Conditions Individuals unable to provide adequate Saliva sample
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome Establishing the potential association between selected Genetic and Epigenetic markers and disease status (Tobacco Chewers belonging to the following 3 Groups Group 1 - Individuals with histopathologically confirmed Oral Squamous Cell Carcinoma (not previously treated for the condition) , n=37 Group 2 - Individuals with histopathologically confirmed Oral Leukoplakia and not previously treated for the condition , n=37 ) Group 3 - Apparently Healthy , Age and Sex matched individuals with normal Oral Mucosa , n=37therby implicating thier role as a potential diagnostic or prognostic biomarker Timepoint: Sample Collection - 6 Months Laboratory Assay and reporting - 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Standardization of usage of saliva as a sample for research on genetic & epigenetic markers ine the mentioned detoxification gene panel. Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr Punnya Angadi
Dr. Prabhakar Kore Basic Science Research Center
Outcome results
None listed