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Effect of propofol on the right hearts ability to pump blood into the lungs effectively

Effect of Propofol on RV PA Coupling in Cardiac Patients undergoing Mitral Valve Surgery with Moderate to Severe Pulmonary Artery Hypertension - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/06/112302
Enrollment
39
Registered
2026-06-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I342- Nonrheumatic mitral (valve) stenosis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Sajeetha R V
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 65 years 2. ASA physical status II or III 3. Scheduled for elective surgery with moderate to severe PAH in NSR 4. Normal systolic function

Exclusion criteria

Exclusion criteria: 1. Refusal to participate 2. Emergency surgery 3. Difficult mask ventilation 4. No TR/Severe TR 5. Atrial fibrillation or any arrythmia 6. Moderate to severe LV dysfunction

Design outcomes

Secondary

MeasureTime frame
Effect of Propofol on 1. RV systolic function indices namely , TAPSE RV FAC ( Fractional Area Change ) S velocity 2. RV Diastolic function Tricuspid inflow: E/A ratio Tricuspid E/e RA (Right Atrium ) area or volume IVC ( Inferior Vena Cava) diameter & collapsibility 3. Effect on pulmonary artery hypertension Pulmonary Artery systolic pressure(PASP): TR velocity Mean Pulmonary artery pressure Pulmonary artery acceleration time RVOT acceleration time 4. Structure parameters: RV basal diameter RV wall thickness RV end-diastolic area/LV end-diastolic area ratio Interventricular septal position /presence of septal flattening 5. HR, Invasive blood pressure(IBP), LV stroke volume, MR severityTimepoint: from the period of preinduction till Bispectral index reaches less than 60—

Primary

MeasureTime frame
Effect of propofol on RV-PA coupling (TAPSE/PASP; RVFAC/PASP; S velocity/PASP)Timepoint: from the period of preinduction till Bispectral index reaches less than 60—

Countries

India

Contacts

Public ContactIra Dhawan

PGIMER, Chandigarh

driradhawan86@gmail.com9646036936

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026