Health Condition 1: G409- Epilepsy, unspecified
Conditions
Interventions
Intervention1: Probiotics: Probiotics sachets for 12 weeks containing (Total-10 billion CFU)
Bididobacterium breve UBBr-01 - 1 billion CFU
Bifidobacterium longum UBBL-64 - 1 billion CFU
Lactobacil
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)
Eligibility
Inclusion criteria
Inclusion criteria: Children with drug resistant epilepsy(based on ILAE definition) aged 1 years to 18 years.
Exclusion criteria
Exclusion criteria: 1.Breastfeeding children. 2.Immunocompromised children. 3.DRE children on a confounding diet(ketogenic diet). 4.Chronic gastrointestinal diseases like IBD,IBS,Celiac disease . 5.Severe Acute malnutrition . 6.Recent or current probiotic/synbiotic usage (within 4 weeks of time of recruitment). 7.Acute infection at the time of recruitment. 8.Recently added anti epileptic medication(3 months). 9.Recent use of antibiotics (within 4 weeks ). Known hypersensitivity to Probiotics. 10.Pseudo Drug resistant Epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the Efficacy of Probiotics in reducing the seizure frequency in Drug Resistant Epilepsy and to assess the responder rate from the baseline i.e more than or equal 50 percentage in seizure reduction. Timepoint: 16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the reduction in levels of IL6 from the baseline. To evaluate the adverse effects associated with Probiotic usage in children. Timepoint: 12 weeks | — |
Countries
India
Contacts
Public ContactDr Tamil Selvan
JIPMER, Puducherry
Outcome results
None listed