Does EGCG medicament lowers the levels of biomarkers in necrotic teeth with symptomatic apical periodontitis

Comparative evaluation of Epigallocatechin gallate and Calcium hydroxide hyphen 2 percent Chlorhexidine intracanal medicaments on inflammatory biomarkers and pain levels in necrotic teeth with symptomatic apical periodontitis hyphen A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112263

Enrollment

Registered

2026-06-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Epigallactocatechin gallate: it is a natural medicament with antibacterial properties frequency- 1 per RCT duration- 14 days Control Intervention1: Calcium Hydroxide with CHX: it is a a

Eligibility

Inclusion criteria

Inclusion criteria: a) Mandibular premolar and canine teeth diagnosed with symptomatic pulp necrosis and symptomatic apical periodontitis b) Patients with age between 18 - 60 years c)Teeth with mature apices

Exclusion criteria

Exclusion criteria: a) Teeth with calcified canals and aberrant root canal morphology. b)Patients with history of allergy to any of the components of local anaesthesia c) Teeth with previous RCT d) Severely damaged or mutilated teeth e)Patient with systemic disease f)Patient with periodontal disease g)Pregnant or lactating women h) Patients with history of allergy to any of the components of green tea

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of EGCC (Epigallocatechin gallate) as an intracana medicament on the level of pain and nflammatory biomarkers (TNF-a, IL-6, IL-1 ) in patients with pulpal necrosis and symptomatic apical periododntitisTimepoint: 1st day and 14th day of the treatment	—

Secondary

Measure	Time frame
to compare level of biomarkers with HPVAS pain scoreTimepoint: baseline level, 7th day & 14th day of the treatment	—

Countries

India

Contacts

Public ContactDrDax

Manav Rachna Dental College Faridabad

alpa.sds@mrei.ac.in9050312010

Outcome results