Health Condition 1: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
BANGALORE BAPTIST HOSPITAL BANGALORE
Eligibility
Inclusion criteria
Inclusion criteria: All adults (18-85 years) presenting to the Rheumatology and Medicine department of BBH and CRICR institute with a new diagnosis of rheumatoid arthritis. All patients with a new or previous diagnosis of Rheumatoid arthritis who have discontinued conventional or biologic DMARDs for more than three months, with the exception of Leflunomide (as its metabolites remain for up to two years)
Exclusion criteria
Exclusion criteria: 1-Patients treated with DMARDs or steroids for more than 1 month 2-Mixed connective tissue disease (MCTD) and other overlap connective tissue diseases with RA component 3-Patients with acute or chronic viral infections like Hepatitis C, HIV or Hepatitis B that preclude the use of conventional and biological DMARDS 4-Patients who experience significant adverse drug events that necessitate discontinuation of the DMARDs during the treatment will be excluded at any point during the study 5-Age above 85 years due to higher risks of infection and other adverse effects with higher doses of Methotrexate or biologic agents for non - responders to conventional DMARDs. 6-Diagnosis of concomitant Interstitial Lung Disease (ILD) complicating Rheumatoid Arthritis. 7-Organ dysfunction: Renal failure- CKD Stage G3 and higher ( Creatinine clearance less than 60 ml/mt). Baseline deranged liver function and chronic liver disease of any aetiology (ethanol abuse or non-alcoholic fatty liver disease - NAFLD or metabolic dysfunction-associated fatty liver disease MAFLD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preliminary estimates of response and non-response rates Timepoint: Response to treatment with conventional DMARDS at the end 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactJACOB MATHEWS VAHANEYIL
BANGALORE BAPTIST HOSPITAL
Outcome results
None listed