To find out phenylehrine effective dose for hypotension following induction A comparative study between healthy donors and liver disease recipients in living donor liver transplantation

Determination of phenylephrine median effective dose for post induction hypotension A comparative study between healthy donors and cirrhotic recipients in living donor liver transplantation - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/06/112167

Enrollment

Registered

2026-06-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K721- Chronic hepatic failure Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Phenylephrine: phenylephrine will be given once there is hypotension following induction of general anaesthesia in cirrhotic recipients undergoing liver transplantation Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: Chronic liver disease patients aged 18 to 65 years undergoing living donor liver transplantation Healthy liver donors aged 18 to 65 years undergoing donor hepatectomy

Exclusion criteria

Exclusion criteria: Paediatric patients Acute liver failure patients Patients on vasopressors preoperatively patients on non selective beta blockers 24 to 48 hours prior to surgery

Design outcomes

Primary

Measure	Time frame
To determine and compare the median effective dose (ED50) of phenylephrine required to increase the mean arterial pressure by 20 percent post induction in cirrhotic recipients and healthy donorsTimepoint: following induction of anaesthesia till 15minutes	—

Secondary

Measure	Time frame
To quantify the adrenergic receptors in cirrhotic hepatic vasculature using RTPCR techniqueTimepoint: samples will be collected from the explanted liver of the recipient & RTPCR will be done towards end of study at 7 months;To find correlation between the preoperative MELD score & the required vasopressor dose in recipient populationTimepoint: preoperatively & after administering drug post induction at 20minutes	—

Measure

Time frame

To quantify the adrenergic receptors in cirrhotic hepatic vasculature using RTPCR techniqueTimepoint: samples will be collected from the explanted liver of the recipient & RTPCR will be done towards end of study at 7 months;To find correlation between the preoperative MELD score & the required vasopressor dose in recipient populationTimepoint: preoperatively & after administering drug post induction at 20minutes

—

Countries

India

Contacts

Public ContactGaurav Sindwani

Institute of liver and biliary sciences

drsindwani25@gmail.com8728089898

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026