Health Condition 1: F54- Psychological and behavioral factors associated with disorders or diseases classified elsewhere
Conditions
Interventions
Intervention1: COGNITIVE BEHAVIOURAL THERAPY: Admission of Cognitive Behavioural Therapy (8-10 sessions) to the recent suicide attempter/ideators (up to 14 days), which fits in the inclusion criteria
instead, they will be under treatment as usual. These will work as controls for the patients who will be given treatment as usual with CBT so that we can monitor the effect of CBT on epigenetics.
Sponsors
ICMR task force AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: History of recent suicide attempt/ current suicidal ideation, without considering whether suicidal behavior was or was not the immediate reason for hospitalization (14 days). If the participant can communicate verbally or in writing in Hindi/English. The participants must be an India citizen descending from Indian parents and grandparents.
Exclusion criteria
Exclusion criteria: History of any chronic inflammatory disease like asthma, cancer, hepatitis, cirrhosis etc. History of medication (medications taken in last 2 months for any chronic illness) History of drug abuse including alcohol (addiction, or intoxicated at the time of suicide attempt). Subjects will be excluded if their self-injurious behaviors determined to have no suicidal Intention or ideation. Patient/ Family members/legal guardian not giving consent Patients with imminent risk of suicide Acute psychosis Acute Mania Severe Cognitive Impairment Emotional dysregulation too severe to process therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in severity of suicidal ideation measured by the Columbia Suicide Severity Rating Scale (CSSRS),Difficulty in Emotional Regulation (DERS), Barrat Impulsivity Scale (BIS), Hospital Anxiety and Depression Scale (HADS) from baseline to 3 months after CBT intervention. The healing effect due to the administration of CBT will be monitored by checking the methylation levels of certain Differentially Methylated Regions of 10 genes which are linked to suicidal behavior.Timepoint: base line, 3 months, 6 months. Blood from the patient will be collected at baseline (after the recent suicide attempt/ideation). Then the patient will be given CBT(10 sessions) and blood will be taken at 3 months to check the effect of CBT on epigenetics. 6 month blood collection would be taken to check the stability of the biomarkers. | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactBhival Nishad
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed